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Affinity label for beta-adrenergic receptor in turkey erythrocytes.火鸡红细胞中β-肾上腺素能受体的亲和标记物。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1921-5. doi: 10.1073/pnas.73.6.1921.
2
Probing of beta-adrenergic receptors by novel fluorescent beta-adrenergic blockers.
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5290-4. doi: 10.1073/pnas.74.12.5290.
3
Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes.火鸡红细胞中β-肾上腺素能受体与腺苷酸环化酶之间的偶联模式。
Biochemistry. 1978 Sep 5;17(18):3795. doi: 10.1021/bi00611a020.
4
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.儿茶酚胺诱导的火鸡红细胞腺苷酸环化酶脱敏。光亲和标记揭示的β-肾上腺素能受体的结构改变。
J Biol Chem. 1982 Aug 25;257(16):9242-5.
5
N-Bromoacetyl-amino-cyanopindolol: a highly potent beta-adrenergic affinity label blocks irreversibly a non-protein component tightly associated with the receptor.
Eur J Biochem. 1985 Jan 2;146(1):9-14. doi: 10.1111/j.1432-1033.1985.tb08613.x.
6
The regulatory control of beta-receptor dependent adenylate cyclase.β受体依赖性腺苷酸环化酶的调节控制
J Supramol Struct. 1976;4(3):405-18. doi: 10.1002/jss.400040311.
7
The binding characteristics and number of beta-adrenergic receptors on the turkey erythrocyte.火鸡红细胞上β-肾上腺素能受体的结合特性及数量
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2773-6. doi: 10.1073/pnas.71.7.2773.
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Beta-adrenergic receptors, cyclic AMP, and ion transport in the avian erythrocyte.禽类红细胞中的β-肾上腺素能受体、环磷酸腺苷与离子转运
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Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.通过亲和色谱法从火鸡红细胞膜中分离无腺苷酸环化酶的β-肾上腺素能受体。
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3710-4. doi: 10.1073/pnas.74.9.3710.
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Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor.普萘洛尔和儿茶酚胺与β-肾上腺素能受体的立体特异性结合。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4246-8. doi: 10.1073/pnas.71.10.4246.

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Studies on agents with mixed NO-dependent vasodilating and beta-blocking activities.
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Photoaffinity label for the beta-adrenergic receptor: synthesis and effects on isoproterenol-stimulated adenylate cyclase.β-肾上腺素能受体的光亲和标记：合成及其对异丙肾上腺素刺激的腺苷酸环化酶的影响。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4449-53. doi: 10.1073/pnas.77.8.4449.
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Association of turkey erythrocyte beta-adrenoceptors with a specific lipid component.火鸡红细胞β-肾上腺素能受体与一种特定脂质成分的关联。
EMBO J. 1986 Jun;5(6):1175-80. doi: 10.1002/j.1460-2075.1986.tb04343.x.
4
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.用吲哚洛尔的溴乙酰衍生物对β-肾上腺素能受体进行不可逆阻断。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Jan;328(3):279-87. doi: 10.1007/BF00515554.
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Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.用长效β-肾上腺素能拮抗剂研究β-肾上腺素能受体数量与生理反应之间的定量关系。
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本文引用的文献

1
The synthesis and local anesthetic properties of aryloxypropanolamines.
J Pharm Pharmacol. 1952 Jan;4(1):21-6. doi: 10.1111/j.2042-7158.1952.tb13106.x.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Haloacetol phosphates. Characterization of the active site of rabbit muscle triose phosphate isomerase.卤代乙酰磷酸。兔肌肉磷酸丙糖异构酶活性位点的表征。
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A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
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5
Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor.普萘洛尔和儿茶酚胺与β-肾上腺素能受体的立体特异性结合。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4246-8. doi: 10.1073/pnas.71.10.4246.
6
The binding characteristics and number of beta-adrenergic receptors on the turkey erythrocyte.火鸡红细胞上β-肾上腺素能受体的结合特性及数量
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2773-6. doi: 10.1073/pnas.71.7.2773.
7
Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase.立体特异性（3H）（负）-阿普洛尔结合位点、β-肾上腺素能受体与腺苷酸环化酶
Biochem Biophys Res Commun. 1974 Sep 23;60(2):703-9. doi: 10.1016/0006-291x(74)90297-6.
8
A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
9
Beta-adrenergic receptor: stereospecific interaction of iodinated beta-blocking agent with high affinity site.β-肾上腺素能受体：碘化β受体阻滞剂与高亲和力位点的立体特异性相互作用。
Science. 1974 Dec 27;186(4170):1223-4. doi: 10.1126/science.186.4170.1223.
10
Ligand specificity and characteristics of the beta-adrenergic receptor in turkey erythrocyte plasma membranes.火鸡红细胞质膜中β-肾上腺素能受体的配体特异性及特性
J Mol Biol. 1975 Sep 5;97(1):35-46.

火鸡红细胞中β-肾上腺素能受体的亲和标记物。

Affinity label for beta-adrenergic receptor in turkey erythrocytes.

作者信息

Atlas D, Steer M L, Levitzki A

出版信息

Proc Natl Acad Sci U S A. 1976 Jun;73(6):1921-5. doi: 10.1073/pnas.73.6.1921.

DOI:10.1073/pnas.73.6.1921
PMID:180528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430419/
Abstract

The compound N-[2-hydroxy-3-(1-naphthoxy)-propyl]-N'-bromoacetylethylenediamine (NHNP-NBE) was found to label covalently the beta-adrenergic receptor in turkey erythrocytes. The compound inhibits irreversibly 1-epinephrine-dependent adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in the whole turkey erythrocyte as well as in the erythrocyte membranes possessing the beta-receptor. The affinity label blocks, also irreversibly, the specific [3H] propranolol binding, whereas other bromoacetyl compounds tested have no effect on binding, even at high concentrations, which cause enzyme inactivation. 1-Epinephrine and propranolol offer protection against the affinity label in whole turkey erythrocytes as well as in membranes prepared from these cells. The potential usefulness of an irreversible beta-antagonist is discussed.

摘要

化合物N-[2-羟基-3-(1-萘氧基)-丙基]-N'-溴乙酰乙二胺（NHNP-NBE）被发现可共价标记火鸡红细胞中的β-肾上腺素能受体。该化合物在整个火鸡红细胞以及具有β-受体的红细胞膜中不可逆地抑制1-肾上腺素依赖性腺苷酸环化酶活性[ATP焦磷酸裂解酶（环化），EC 4.6.1.1]。亲和标记也不可逆地阻断特异性[3H]普萘洛尔结合，而测试的其他溴乙酰化合物即使在高浓度下也对结合无影响，高浓度会导致酶失活。1-肾上腺素和普萘洛尔在整个火鸡红细胞以及从这些细胞制备的膜中对亲和标记具有保护作用。讨论了不可逆β拮抗剂的潜在用途。