Duerr Felix M, Duncan Colleen G, Savicky Roman S, Park Richard D, Egger Erick L, Palmer Ross H
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
J Am Vet Med Assoc. 2007 Dec 1;231(11):1688-91. doi: 10.2460/javma.231.11.1688.
To identify risk factors for development of excessive tibial plateau angle (TPA) in large-breed dogs with cranial cruciate ligament disease (CCLD).
Case-control study.
58 dogs with excessive TPAs (ie, TPA >or= 35 degrees ; case dogs) and 58 dogs with normal TPAs (ie, TPA <or= 30 degrees ; control dogs).
Medical records and radiographs were reviewed and owners were interviewed to identify potential risk factors for excessive TPA.
Case dogs were 3 times (95% confidence interval, 1.2 to 8.0) as likely to have been neutered before 6 months of age as were control dogs. Case dogs with TPA >or= 35 degrees in both limbs were 13.6 times (95% confidence interval, 2.72 to 68.1) as likely to have been neutered before 6 months of age as were control dogs with TPA <or= 30 degrees in both limbs. Case dogs were significantly younger at the onset of hind limb lameness than were control dogs.
Results suggested that early neutering was a significant risk factor for development of excessive TPA in large-breed dogs with CCLD. Further research into the effects of early neutering on TPA and the pathophysiology of CCLD is warranted.
确定患有颅交叉韧带疾病（CCLD）的大型犬发生胫骨平台角（TPA）过大的风险因素。
病例对照研究。
58只TPA过大的犬（即TPA≥35度；病例组犬）和58只TPA正常的犬（即TPA≤30度；对照组犬）。
查阅病历和X光片，并对犬主进行访谈，以确定TPA过大的潜在风险因素。
病例组犬在6月龄前绝育的可能性是对照组犬的3倍（95%置信区间，1.2至8.0）。双肢TPA≥35度的病例组犬在6月龄前绝育的可能性是双肢TPA≤30度的对照组犬的13.6倍（95%置信区间，2.72至68.1）。病例组犬后肢跛行开始时的年龄显著小于对照组犬。
结果表明，早期绝育是患有CCLD的大型犬发生TPA过大的一个重要风险因素。有必要进一步研究早期绝育对TPA的影响以及CCLD的病理生理学。
