Willig F, M'Harzi M, Delacour J
Laboratoire de Psychophysiologie, Université Paris 7, France.
Physiol Behav. 1991 Nov;50(5):913-9. doi: 10.1016/0031-9384(91)90414-j.
Performances of male rats of the Roman High (RHA)- and Roman Low (RLA)-Avoidance strains were compared along four essential dimensions: working memory, reference memory, spontaneous locomotion and avoidance conditioning. Performances of RLA and RHA rats were significantly different for each dimension. As constantly reported, RHA rats were by far superior to RLA in avoidance conditioning. They had also higher levels of locomotor activity. On the opposite, RLA performed better than RHA in an appetitive working memory task, the delayed reinforced alternation, and were also superior in an appetitive reference memory task, the 5-unit linear maze. These results confirm the fact that RLA rats may acquire positively reinforced learning more rapidly than RHA rats and that the differences in active avoidance behavior between the two strains depend more on differential freezing behavior than on learning or memory capacities. Beyond the problem of the characterization of the Roman strains, these data might give indications on the relationships between behavioral tests widely used in rats, and on their use as memory models.
对罗马高回避（RHA）品系和罗马低回避（RLA）品系的雄性大鼠在四个基本维度上的表现进行了比较：工作记忆、参考记忆、自发运动和回避条件反射。RLA和RHA大鼠在每个维度上的表现都有显著差异。正如一直报道的那样，RHA大鼠在回避条件反射方面远远优于RLA大鼠。它们的运动活动水平也更高。相反，RLA大鼠在一项奖赏性工作记忆任务（延迟强化交替）中表现优于RHA大鼠，并且在一项奖赏性参考记忆任务（5单元线性迷宫）中也更胜一筹。这些结果证实了这样一个事实，即RLA大鼠可能比RHA大鼠更快地获得正强化学习，并且这两个品系在主动回避行为上的差异更多地取决于不同的僵住行为，而不是学习或记忆能力。除了罗马品系的特征描述问题之外，这些数据可能为大鼠中广泛使用的行为测试之间的关系及其作为记忆模型的用途提供线索。
