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大鼠罗马品系的心理生理特征

Psychophysiological profiles of the Roman strains of rats.

作者信息

Guenaire C, Feghali G, Senault B, Delacour J

出版信息

Physiol Behav. 1986;37(3):423-8. doi: 10.1016/0031-9384(86)90200-3.

DOI:10.1016/0031-9384(86)90200-3
PMID:3092252
Abstract

Male rats of the Roman High and Roman Low Avoidance strains were submitted to four principal behavioral tests: food-motivated acquisition of bar-pressing in Skinner box, delayed reinforced alternation, locomotor activity in a "multibox apparatus," conditioned suppression, and two biological measures: blood pressure and brain octopamine level. Performances of RLA and RHA rats were significantly different in each behavioral test. Blood pressure was higher in RHA, but the difference only approached the 0.05 threshold. As previously reported, brain octopamine levels of RHA rats were significantly higher than those of RLA. A multivariate treatment (analysis of correspondences) was applied to the data of 10 behavioral tests. The main factor extracted by this treatment clearly separated the two strains. Among the variables which best differentiate RHA and RLA rats, several do not involve stress (working memory, acquisition of bar-pressing, and locomotor activity).

摘要

选用罗马高回避和罗马低回避品系的雄性大鼠进行四项主要行为测试

斯金纳箱中以食物为动机的压杆习得、延迟强化交替、“多箱装置”中的运动活动、条件性抑制,以及两项生物学指标:血压和脑内章鱼胺水平。在每项行为测试中,RLA和RHA大鼠的表现均存在显著差异。RHA大鼠的血压较高,但差异仅接近0.05的阈值。如先前报道,RHA大鼠的脑内章鱼胺水平显著高于RLA大鼠。对10项行为测试的数据进行了多变量处理(对应分析)。该处理提取的主要因素清晰地分离了这两个品系。在最能区分RHA和RLA大鼠的变量中,有几个与应激无关(工作记忆、压杆习得和运动活动)。

相似文献

1
Psychophysiological profiles of the Roman strains of rats.大鼠罗马品系的心理生理特征
Physiol Behav. 1986;37(3):423-8. doi: 10.1016/0031-9384(86)90200-3.
2
Differential acquisition of a "working memory" task by the Roman strains of rats.大鼠罗马品系对“工作记忆”任务的差异性习得
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Contribution of the Roman strains of rats to the elaboration of animal models of memory.大鼠罗马品系对记忆动物模型构建的贡献。
Physiol Behav. 1991 Nov;50(5):913-9. doi: 10.1016/0031-9384(91)90414-j.
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Roman strains as a psychogenetic model for the study of working memory: behavioral and biochemical data.作为工作记忆研究心理遗传学模型的罗马品系:行为学和生物化学数据
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Two-way avoidance behavior of the roman rat strains following brain lesions.脑损伤后罗马大鼠品系的双向回避行为。
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The partial reinforcement extinction effect (PREE) in female Roman high- (RHA-I) and low-avoidance (RLA-I) rats.雌性罗马高回避(RHA-I)和低回避(RLA-I)大鼠的部分强化消退效应(PREE)
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The Roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656.作为工作记忆药理学研究心理遗传学工具的罗马品系大鼠:以RU 41656为例
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Volumetric brain differences between the Roman rat strains: Neonatal handling effects, sensorimotor gating and working memory.罗马大鼠品系之间的脑容量差异:新生期处理效应、感觉运动门控和工作记忆。
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Incentive loss and hippocampal gene expression in inbred Roman high- (RHA-I) and Roman low- (RLA-I) avoidance rats.近交系 Roman 高回避(RHA-I)和 Roman 低回避(RLA-I)大鼠的激励损失和海马基因表达。
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Genetic and environmental influences on behavioral and neurochemical aspects of emotionality in rats.遗传和环境对大鼠情绪行为及神经化学方面的影响。
Experientia. 1988 Jun 15;44(6):482-90. doi: 10.1007/BF01958922.
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The Roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656.
作为工作记忆药理学研究心理遗传学工具的罗马品系大鼠:以RU 41656为例
Psychopharmacology (Berl). 1992;107(2-3):415-24. doi: 10.1007/BF02245169.