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Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes.克隆性成肌细胞向类似软骨细胞的细胞进行表型转化。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1989-93. doi: 10.1073/pnas.73.6.1989.
2
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Differentiation and de-differentiation of cultured chondrocytes: increase in monomeric size of 'cartilage-specific' proteoglycans by dibutyryl cyclic AMP and complete inhibition of their synthesis by retinoic acid.培养软骨细胞的分化与去分化：二丁酰环磷腺苷使“软骨特异性”蛋白聚糖单体大小增加，视黄酸则完全抑制其合成。
Biochem Int. 1985 Feb;10(2):267-72.
4
Cyclic AMP and cell behavior in cultured cells.环磷酸腺苷与培养细胞中的细胞行为
Int Rev Cytol. 1976;44:319-63. doi: 10.1016/s0074-7696(08)61652-6.
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Restoration by parathyroid hormone and dibutyryl cyclic AMP of expression of the differentiated phenotype of chondrocytes inhibited by a tumor promoter, 12-0-tetradecanoylphorbol-13-acetate.甲状旁腺激素和二丁酰环磷酸腺苷对被肿瘤启动子12-0-十四酰佛波醇-13-乙酸酯抑制的软骨细胞分化表型表达的恢复作用
Cell Differ. 1983 Dec;13(4):283-91. doi: 10.1016/0045-6039(83)90038-6.
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Effect of cyclic AMP on growth and morphological differentiation of an established myogenic cell line.环磷酸腺苷对已建立的成肌细胞系生长和形态分化的影响。
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Effects of parathyroid hormone and cyclic AMP analogues on the activity of ornithine decarboxylase and expression of the differentiated phenotype of chondrocytes in culture.甲状旁腺激素和环磷酸腺苷类似物对培养的软骨细胞中鸟氨酸脱羧酶活性及分化表型表达的影响。
J Cell Physiol. 1981 Feb;106(2):259-68. doi: 10.1002/jcp.1041060212.
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Effect of dibutyryl cyclic AMP on collagen synthesis in a clonal osteoblast-like cell line derived from newborn mouse calvaria.二丁酰环磷腺苷对源自新生小鼠颅骨的克隆成骨样细胞系中胶原蛋白合成的影响。
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Forskolin- and dibutyryl cyclic AMP-mediated inhibition of chondrogenesis.毛喉素和二丁酰环磷酸腺苷介导的软骨生成抑制作用
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The effect of parathyroid hormone (1-34) on cyclic AMP level, ornithine decarboxylase activity, and glycosaminoglycan synthesis of chondrocytes from mandibular condylar cartilage, nasal septal cartilage, and spheno-occipital synchondrosis in culture.甲状旁腺激素（1-34）对培养的下颌髁突软骨、鼻中隔软骨和蝶枕软骨结合处软骨细胞中环磷酸腺苷水平、鸟氨酸脱羧酶活性及糖胺聚糖合成的影响。
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本文引用的文献

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ISOLATION OF MUCOPOLYSACCHARIDE FROM THE PRECARTILAGINOUS EMBRYONIC CHICK LIMB BUD.从鸡胚胎软骨前肢芽中分离黏多糖
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The in vitro cultivation and differentiation capacities of myogenic cell lines.成肌细胞系的体外培养和分化能力。
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Nerve-muscle interaction in vitro. Role of acetylcholine.体外神经-肌肉相互作用。乙酰胆碱的作用。
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Appearance of acetylcholine receptors during differentiation of a myogenic cell line.乙酰胆碱受体在成肌细胞系分化过程中的出现。
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Synapse formation between clonal muscle cells and rat spinal cord explants.克隆肌肉细胞与大鼠脊髓外植体之间的突触形成。
Nature. 1974 Dec 13;252(5484):593-4. doi: 10.1038/252593a0.
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Nicotinamide inhibition of 3',5'-cyclic AMP phosphodiesterase in vitro.烟酰胺在体外对3',5'-环磷酸腺苷磷酸二酯酶的抑制作用。
Biochem Biophys Res Commun. 1972 Nov 15;49(4):1137-41. doi: 10.1016/0006-291x(72)90331-2.
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Alterations of enzymatic activities during muscle differentiation in vitro.体外肌肉分化过程中酶活性的变化。
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克隆性成肌细胞向类似软骨细胞的细胞进行表型转化。

Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes.

作者信息

Schubert D, Lacorbiere M

出版信息

Proc Natl Acad Sci U S A. 1976 Jun;73(6):1989-93. doi: 10.1073/pnas.73.6.1989.

DOI:10.1073/pnas.73.6.1989
PMID:180533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430433/
Abstract

The nicotinamide analogue 6-aminonicotinamide and dibutyryl 3':5'-cAMP inhibit myogenesis in a clonal rat cell line from skeletal muscle. Both reagents produce a similar morphological response in the cells, and stimulate collagen and glycosaminoglycan synthesis. These data suggest that 6-aminonicotinamide and dibutyryl cAMP induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes.

摘要

烟酰胺类似物6-氨基烟酰胺和二丁酰3':5'-环磷酸腺苷抑制来自骨骼肌的克隆大鼠细胞系中的肌生成。这两种试剂在细胞中产生相似的形态学反应，并刺激胶原蛋白和糖胺聚糖的合成。这些数据表明，6-氨基烟酰胺和二丁酰环磷酸腺苷诱导肌原细胞向与软骨细胞具有许多共同特征的细胞发生表型转化。