克隆性成肌细胞向类似软骨细胞的细胞进行表型转化。
Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes.
作者信息
Schubert D, Lacorbiere M
出版信息
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1989-93. doi: 10.1073/pnas.73.6.1989.
Abstract
The nicotinamide analogue 6-aminonicotinamide and dibutyryl 3':5'-cAMP inhibit myogenesis in a clonal rat cell line from skeletal muscle. Both reagents produce a similar morphological response in the cells, and stimulate collagen and glycosaminoglycan synthesis. These data suggest that 6-aminonicotinamide and dibutyryl cAMP induce a phenotypic transformation of myogenic cells to cells that share many characteristics with chondrocytes.
摘要
烟酰胺类似物6-氨基烟酰胺和二丁酰3':5'-环磷酸腺苷抑制来自骨骼肌的克隆大鼠细胞系中的肌生成。这两种试剂在细胞中产生相似的形态学反应，并刺激胶原蛋白和糖胺聚糖的合成。这些数据表明，6-氨基烟酰胺和二丁酰环磷酸腺苷诱导肌原细胞向与软骨细胞具有许多共同特征的细胞发生表型转化。
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