T细胞中CXCR4依赖性信号传导的细胞内介质。
Intracellular mediators of CXCR4-dependent signaling in T cells.
作者信息
Patrussi Laura, Baldari Cosima T
机构信息
Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
出版信息
Immunol Lett. 2008 Jan 29;115(2):75-82. doi: 10.1016/j.imlet.2007.10.012. Epub 2007 Nov 20.
PMID:18054087
Abstract
The signaling pathways induced in T lymphocytes by CXCR4-CXCL12 interaction, which lead to the cytoskeletal macro-rearrangements observable in migrating cells, are as yet largely uncharacterized. The aim of this review is to briefly summarize the current knowledge of the signaling machinery which controls the process of chemotaxis in CXCL12-stimulated T lymphocytes.
摘要
由CXCR4-CXCL12相互作用在T淋巴细胞中诱导产生的信号通路，会导致迁移细胞中可观察到的细胞骨架宏观重排，而目前对这些信号通路的了解还很有限。这篇综述的目的是简要总结目前关于控制CXCL12刺激的T淋巴细胞趋化过程的信号传导机制的知识。
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