基于C60的活性酯的制备以及C60部分与胺或醇的偶联。
Preparation of C60-based active esters and coupling of C60 moiety to amines or alcohols.
作者信息
Tsumoto Hiroki, Takahashi Katsumasa, Suzuki Takayoshi, Nakagawa Hidehiko, Kohda Kohfuku, Miyata Naoki
机构信息
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Nagoya, Aichi 467-8603, Japan.
出版信息
Bioorg Med Chem Lett. 2008 Jan 15;18(2):657-60. doi: 10.1016/j.bmcl.2007.11.065. Epub 2007 Nov 22.
We report the syntheses of C(60)-based active esters and the coupling of their C(60) moiety to various amines or alcohols. Methano[60]fullerene carboxylic acid was activated by esterification with N-hydroxysuccinimide (NHS) or pentafluorophenol (PFP) and the active esters were isolated. Reactions of the active esters with amines or alcohols proceeded easily to give a variety of compounds having the C(60) moiety.
我们报道了基于C(60)的活性酯的合成及其C(60)部分与各种胺或醇的偶联反应。通过与N-羟基琥珀酰亚胺（NHS）或五氟苯酚（PFP）酯化，将甲氧基[60]富勒烯羧酸活化，分离得到活性酯。活性酯与胺或醇的反应很容易进行，生成了多种含有C(60)部分的化合物。
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