首发精神病巴西患者的灰质异常
Grey matter abnormalities in Brazilians with first-episode psychosis.
作者信息
Schaufelberger Maristela S, Duran Fabio L S, Lappin Julia M, Scazufca Marcia, Amaro Edson, Leite Claudia C, de Castro Claudio C, Murray Robin M, McGuire Philip K, Menezes Paulo R, Busatto Geraldo F
机构信息
Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos, s/n, CEP 05403-903, São Paulo, SP Brazil.
出版信息
Br J Psychiatry Suppl. 2007 Dec;51:s117-22. doi: 10.1192/bjp.191.51.s117.
BACKGROUND
In low- and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countries.
AIMS
To examine structural brain differences in people with first-episode psychosis and controls in Brazil.
METHOD
Magnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controls.
RESULTS
There were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controls.
CONCLUSIONS
Structural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil.
背景
据报道，中低收入国家精神分裂症患者的预后比高收入国家的患者更好。
目的
研究巴西首发精神病患者与对照组在脑结构上的差异。
方法
对122例首发精神病患者和94例对照者进行基于体素的形态学磁共振成像检查。
结果
首发精神病患者左侧颞上回、额下前皮质、双侧脑岛及右侧海马区灰质显著减少（P<0.05，经多重比较校正）。精神分裂症亚组（n=62）相对于对照组也表现出类似的灰质减少模式。
结论
高收入国家报道的精神病患者脑结构异常在巴西首发精神病患者中也存在。
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