Arabia Gennarina, Grossardt Brandon R, Geda Yonas E, Carlin Justin M, Bower James H, Ahlskog J Eric, Maraganore Demetrius M, Rocca Walter A
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Arch Gen Psychiatry. 2007 Dec;64(12):1385-92. doi: 10.1001/archpsyc.64.12.1385.
Relatives of patients with Parkinson disease (PD) have an increased risk of PD and other neurologic disorders; however, their risk of psychiatric disorders remains uncertain.
To study the risk of depressive disorders and anxiety disorders among first-degree relatives of patients with PD compared with first-degree relatives of controls.
DESIGN, SETTING, AND PARTICIPANTS: In a population-based, historical cohort study, we included 1000 first-degree relatives of 162 patients with PD and 850 first-degree relatives of 147 controls. Both patients with PD and controls were representative of the population of Olmsted County, Minnesota.
Documentation of psychiatric disorders was obtained for each relative separately through a combination of telephone interviews with the relatives (or their proxies) and review of their medical records from a records-linkage system (family study method). Psychiatric disorders were defined using clinical criteria from the DSM-IV or routine diagnoses.
We found an increased risk of several psychiatric disorders in first-degree relatives of patients with PD compared with first-degree relatives of controls (hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.21-1.95; P <.001). In particular, we found an increased risk of depressive disorders (HR, 1.45; 95% CI, 1.11-1.89; P = .006) and anxiety disorders (HR, 1.55; 95% CI, 1.05-2.28; P = .03). The results were consistent in analyses that adjusted for type of interview, excluded relatives who developed parkinsonism, or excluded relatives who developed both a depressive disorder and an anxiety disorder.
These findings suggest that depressive disorders and anxiety disorders may share familial susceptibility factors with PD.
帕金森病（PD）患者的亲属患帕金森病及其他神经系统疾病的风险增加；然而，他们患精神疾病的风险仍不确定。
研究帕金森病患者的一级亲属与对照者的一级亲属相比，患抑郁症和焦虑症的风险。
设计、地点和参与者：在一项基于人群的历史性队列研究中，我们纳入了162例帕金森病患者的1000名一级亲属和147名对照者的850名一级亲属。帕金森病患者和对照者均代表明尼苏达州奥尔姆斯特德县的人群。
通过与亲属（或其代理人）进行电话访谈以及查阅记录链接系统中的病历（家族研究方法），分别为每位亲属获取精神疾病的记录。使用《精神疾病诊断与统计手册》第四版（DSM-IV）的临床标准或常规诊断来定义精神疾病。
我们发现，与对照者的一级亲属相比，帕金森病患者的一级亲属患几种精神疾病的风险增加（风险比[HR]，1.54；95%置信区间[CI]，1.21 - 1.95；P <.001）。特别是，我们发现患抑郁症的风险增加（HR，1.45；95% CI，1.11 - 1.89；P =.006）和患焦虑症的风险增加（HR，1.55；95% CI，1.05 - 2.28；P =.03）。在对访谈类型进行调整、排除患帕金森综合征的亲属或排除同时患抑郁症和焦虑症的亲属的分析中，结果是一致的。
这些发现表明，抑郁症和焦虑症可能与帕金森病共享家族易感性因素。
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