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Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.
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Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
Mol Cancer Ther. 2007 Apr;6(4):1357-67. doi: 10.1158/1535-7163.MCT-06-0476.
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Cellular characterization of a novel focal adhesion kinase inhibitor.
J Biol Chem. 2007 May 18;282(20):14845-52. doi: 10.1074/jbc.M606695200. Epub 2007 Mar 28.
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Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics.
Mol Ther. 2007 Mar;15(3):515-23. doi: 10.1038/sj.mt.6300072. Epub 2007 Feb 6.
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Integrin-regulated FAK-Src signaling in normal and cancer cells.
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Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.
Oncogene. 2006 Jul 27;25(32):4429-40. doi: 10.1038/sj.onc.1209482. Epub 2006 Mar 20.
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FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion.
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Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.
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