Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Department of Urology, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Breast Cancer Res. 2022 Dec 29;24(1):99. doi: 10.1186/s13058-022-01596-y.
Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven members sharing similar structure and function. Among them, SRC is the first identified proto-oncogene in mammalian cells. Oncogenic overexpression or activation of SRC has been revealed to play essential roles in multiple events of BC progression, including tumor initiation, growth, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of SRC kinase and SRC-relevant functions in various subtypes of BC and then systematically summarize SRC-mediated signaling transductions, with particular emphasis on SRC-mediated substrate phosphorylation in BC. Furthermore, we will discuss the progress of SRC-based targeted therapies in BC and the potential future direction.
乳腺癌（BC）已成为全球最常见的恶性肿瘤，也是女性癌症相关死亡的主要原因。Src 家族激酶（SFKs）属于非受体酪氨酸激酶（nRTK）家族，该家族共有 11 个成员，具有相似的结构和功能。其中，Src 是哺乳动物细胞中第一个被鉴定的原癌基因。研究表明，Src 的致癌过表达或激活在乳腺癌进展的多个事件中发挥着重要作用，包括肿瘤起始、生长、转移、耐药性和干性调节。在这篇综述中，我们首先概述了 SRC 激酶及其在各种亚型乳腺癌中的相关功能，然后系统地总结了 SRC 介导的信号转导，特别强调了 SRC 介导的乳腺癌中底物磷酸化。此外，我们还讨论了基于 SRC 的靶向治疗在乳腺癌中的进展和潜在的未来方向。
