Nikolaus Nadja V, Bozilović Jelena, Engels Joachim W
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):889-92. doi: 10.1080/15257770701505485.
During the last decades the nucleoside synthesis has proven to be important. The modified silyl-Hilbert-Johnson nucleoside synthesis modified by Vorbrüggen is one of the most often used methods. We have studied N-glycosilation of modifieded heterocyclic bases by Vorbrüggen method with microwave irradiation and we were able to shorten the reaction time and obtain higher yields. The method was demonstrated by fluoroquinolone and purine.
在过去几十年中，核苷合成已被证明是重要的。由Vorbrüggen改进的硅烷基-希尔伯特-约翰逊核苷合成法是最常用的方法之一。我们研究了通过Vorbrüggen法利用微波辐射对修饰的杂环碱基进行N-糖基化反应，并且能够缩短反应时间并获得更高的产率。该方法已通过氟喹诺酮和嘌呤得到验证。
