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5'-carbamoylphosphonyl-[6-3H]-AZT as a tool for studying metabolic transformations of the nonradioactive counterpart, an inhibitor of HIV replication.

作者信息

Yanvarev Dmitry V, Shirokova Elena A, Astapova Maria V, Shram Vyacheslav I, Kukhanova Marina K, Skoblov Yury S

机构信息

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):897-900. doi: 10.1080/15257770701505899.

DOI:10.1080/15257770701505899
PMID:18058504
Abstract

An effective synthesis of 5'-carbamoylphosphonyl-[6-3H]-AZT was developed from [6-3H]-AZT. For the synthesized compound, chemical and enzymatic stability were determined and its penetration across HL-60 cell membranes was studied.

摘要

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