一个包含3'-3'和5'-5'极性位点反转的TBA类似物微型文库。
A mini-library of TBA analogues containing 3'-3' and 5'-5' inversion of polarity sites.
作者信息
Esposito V, Galeone A, Mayol L, Randazzo A, Virgilio A, Virno A
机构信息
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1145-9. doi: 10.1080/15257770701526978.
Several researches have been devoted to structure-activity relationship and to post-SELEX modifications of the thrombin binding aptamer (TBA), one of the first aptamers discovered by the SELEX methodology. However, no studies on TBA dealing with the effects of introduction of inversion of polarity sites have been reported yet. In this frame, we have undertaken the synthesis and the study of a mini-library composed of several TBA analogues containing a 3'-3' or a 5'-5' inversion of polarity site at different positions into the sequence. Particularly, in this article, we present preliminary results about their structural and biological properties.
多项研究致力于凝血酶结合适体（TBA）的构效关系及SELEX后修饰，TBA是通过SELEX方法发现的首批适体之一。然而，尚未有关于TBA引入极性反转位点影响的研究报道。在此背景下，我们开展了一个小型文库的合成与研究，该文库由多个TBA类似物组成，这些类似物在序列的不同位置含有3'-3'或5'-5'极性反转位点。特别地，在本文中，我们展示了关于它们结构和生物学特性的初步结果。
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