Chiromatzo A O, Oliveira T Y K, Pereira G, Costa A Y, Montesco C A E, Gras D E, Yosetake F, Vilar J B, Cervato M, Prado P R R, Cardenas R G C C L, Cerri R, Borges R L, Lemos R N, Alvarenga S M, Perallis V R C, Pinheiro D G, Silva I T, Brandão R M, Cunha M A V, Giuliatti S, Silva W A
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Genet Mol Res. 2007 Oct 5;6(4):859-65.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsically related to metabolic pathways. This leads to questions that are particularly interesting for investigating medical and laboratorial applications. We developed an miRNApath online database that uses miRNA target genes to link miRNAs to metabolic pathways. Currently, databases about miRNA target genes (DIANA miRGen), genomic maps (miRNAMap) and sequences (miRBase) do not provide such correlations. Additionally, miRNApath offers five search services and a download area. For each search, there is a specific type of input, which can be a list of target genes, miRNAs, or metabolic pathways, which results in different views, depending upon the input data, concerning relationships between the target genes, miRNAs and metabolic pathways. There are also internal links that lead to a deeper analysis and cross-links to other databases with more detailed information. miRNApath is being continually updated and is available at http://lgmb.fmrp.usp.br/mirnapath.
微小RNA（miRNA）是一类小的非编码RNA，它们可调节靶基因的表达，因此在代谢途径中发挥重要作用。最近的研究证实了miRNA与细胞增殖、分化、发育及疾病之间的相互关系。由于它们参与基因调控，所以与代谢途径存在内在联系。这引发了一些对于研究医学和实验室应用特别有趣的问题。我们开发了一个名为miRNApath的在线数据库，该数据库利用miRNA靶基因将miRNA与代谢途径联系起来。目前，有关miRNA靶基因的数据库（DIANA miRGen）、基因组图谱（miRNAMap）和序列（miRBase）并未提供此类关联信息。此外，miRNApath提供五种搜索服务和一个下载区域。对于每次搜索，都有特定类型的输入，输入内容可以是靶基因列表、miRNA或代谢途径，根据输入数据的不同，会呈现出关于靶基因、miRNA和代谢途径之间关系的不同视图。该数据库还有内部链接可进行更深入的分析，以及与其他包含更详细信息的数据库的交叉链接。miRNApath正在持续更新，可通过http://lgmb.fmrp.usp.br/mirnapath访问。
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