Hinton Ladson, Tomaszewski Farias Sarah, Wegelin Jacob
Department of Psychiatry and Alzheimer's Disease Center, University of California, CA, USA.
Int J Geriatr Psychiatry. 2008 Jan;23(1):102-8. doi: 10.1002/gps.1952.
To examine the relationship between neuropsychiatric symptoms burden and disability in cognitively impaired older Latinos.
Subjects in the cross-sectional study were 95 cognitively impaired (both demented and non-demented) non-institutionalized Latino elderly participating in an epidemiological cohort study and their family caregivers. Care recipient neuropsychiatric symptoms (Neuropsychiatric Inventory) and level of functional impairment (i.e. impairment in activities of daily living and instrumental activities of daily living) were assessed through interviews with family caregivers.
Both NPI total score and NPI depression subscale score were significantly associated with disability before and after controlling for potential confounding variables. The strength of the association between higher neuropsychiatric symptom levels and higher disability was similar for both the cognitively impaired not demented and demented groups.
Neuropsychiatric symptoms are associated with increased disability in a community sample of cognitively impaired Latino elderly. More effective identification and treatment of neuropsychiatric symptoms may improve functioning in older Latinos and reduce health disparities for this population.
探讨认知受损的老年拉丁裔人群中神经精神症状负担与残疾之间的关系。
该横断面研究的受试者为95名参与一项流行病学队列研究的认知受损(包括痴呆和非痴呆)的非机构化拉丁裔老年人及其家庭照顾者。通过与家庭照顾者访谈,评估受照顾者的神经精神症状(神经精神症状问卷)和功能损害水平(即日常生活活动和工具性日常生活活动的损害)。
在控制潜在混杂变量前后,神经精神症状问卷总分和神经精神症状问卷抑郁分量表得分均与残疾显著相关。认知受损但未患痴呆组和痴呆组中,较高的神经精神症状水平与较高的残疾之间的关联强度相似。
在认知受损的拉丁裔老年社区样本中,神经精神症状与残疾增加有关。更有效地识别和治疗神经精神症状可能会改善老年拉丁裔人群的功能,并减少该人群的健康差距。