Scardina Giuseppe Alessandro, Fucà Gerlandina, Carini Francesco, Valenza Vincenzo, Spicola Michele, Procaccianti Paolo, Messina Pietro, Maresi Emiliano
Department of Oral Science-University of Palermo, Italy.
Med Oral Patol Oral Cir Bucal. 2007 Dec 1;12(8):E560-4.
Kawasaki disease (KD) was first described in 1967 by Kawasaki, who defined it as "mucocutaneous lymph node syndrome". KD is an acute systemic vasculitis, which mainly involves medium calibre arteries; its origin is unknown, and it is observed in children under the age of 5, especially in their third year. The principal presentations of KD include fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy. Within KD, oral mucositis - represented by diffuse mucous membrane erythema, lip and tongue reddening and lingual papillae hypertrophy with subsequent development of strawberry tongue - can occur both in the acute stage of the disease (0-9 days), and in the convalescence stage (>25 days) as a consequence of the pharmacological treatment. KD vascular lesions are defined as systemic vasculitis instead of systemic arteritis. This study analyzed the anatomical-pathological substrata of oral mucositis in a baby affected by Kawasaki disease and suddenly deceased for cardiac tamponade caused by coronary aneurysm rupture (sudden cardiac death of a mechanical type).
川崎病（KD）于1967年由川崎首次描述，他将其定义为“黏膜皮肤淋巴结综合征”。KD是一种急性全身性血管炎，主要累及中等口径动脉；其病因不明，多见于5岁以下儿童，尤其是3岁左右的儿童。KD的主要表现包括发热、双侧非渗出性结膜炎、唇及口腔黏膜红斑、四肢变化、皮疹和颈部淋巴结肿大。在KD中，以弥漫性黏膜红斑、唇舌发红和舌乳头肥大并随后发展为草莓舌为特征的口腔黏膜炎，可发生在疾病的急性期（0 - 9天），也可因药物治疗而在恢复期（>25天）出现。KD血管病变被定义为全身性血管炎而非全身性动脉炎。本研究分析了一名患有川崎病的婴儿因冠状动脉瘤破裂导致心脏压塞（机械性猝死）而突然死亡时口腔黏膜炎的解剖病理学基础。
