Tascini C, Urbani L, Biancofiore G, Rossolini G M, Leonildi A, Gemignani G, Bindi M L, Mugnaioli C, Filipponi F, Menichetti F
Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Minerva Anestesiol. 2008 Jan-Feb;74(1-2):47-9. Epub 2007 Dec 3.
A case of bla(VIM-1) producing E. cloacae disseminated infection in a patient submitted to orthotopic liver transplantation is described. Synergism between colistin, rifampin and imipenem was studied in vitro and this combination of three drugs was used to treat E. cloacae infection. The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy.
本文描述了1例接受原位肝移植患者发生产bla(VIM-1)阴沟肠杆菌播散性感染的病例。体外研究了黏菌素、利福平和亚胺培南之间的协同作用，并使用这三种药物联合治疗阴沟肠杆菌感染。结果表明，该联合用药具有协同活性，与先前治疗期间采集的血清杀菌活性相比，血清杀菌活性有所增强。
