志贺氏菌效应蛋白的多功能性。

The versatility of Shigella effectors.

作者信息

Ogawa Michinaga, Handa Yutaka, Ashida Hiroshi, Suzuki Masato, Sasakawa Chihiro

机构信息

Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

出版信息

Nat Rev Microbiol. 2008 Jan;6(1):11-6. doi: 10.1038/nrmicro1814.

DOI:10.1038/nrmicro1814

PMID:18059288

Abstract

When Shigella infect the intestinal epithelium, they deliver several effectors through the type III secretion system (T3SS) into the surrounding space and directly into the host-cell cytoplasm, where they can mimic and usurp host cellular functions or subvert host-cell signalling pathways and the immune response. Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection.

摘要

当志贺氏菌感染肠道上皮细胞时，它们通过III型分泌系统（T3SS）将多种效应蛋白释放到周围空间并直接释放到宿主细胞的细胞质中，在那里它们可以模拟并篡夺宿主细胞功能，或破坏宿主细胞的信号通路和免疫反应。尽管细菌的感染策略和机制差异很大，但最近对志贺氏菌效应蛋白的研究表明，志贺氏菌拥有一种高度进化的感染策略。