Department of Pharmacology, Kasturba Medical College, Manipal University, Light House Hill Road, Mangalore 1, Karnataka, India.
Reprod Biol. 2007 Nov;7(3):247-51.
The objective of the present study was to investigate the effects of the antiepileptic drugs, gabapentin and phenytoin, on sperm morphology in Wistar rats. Groups (n=5) of rats were treated with cyclophosphamide (20 mg/day), gabapentin (16, 25, 32 mg/day) and phenytoin (3.5, 5.5, 7 mg/day) for five consecutive days. 14 and 35 days after the last exposure, sperm morphology was evaluated by standard procedure. Gabapentin and phenytoin did not induce significant changes in sperm morphology. The results suggest that phenytoin and gabapentin are not germ cell mutagens in males, and do not appear to adversely affect male fertility.
本研究的目的是探讨抗癫痫药物加巴喷丁和苯妥英对 Wistar 大鼠精子形态的影响。 实验组（n=5）的大鼠连续五天接受环磷酰胺（20mg/天）、加巴喷丁（16、25、32mg/天）和苯妥英（3.5、5.5、7mg/天）治疗。最后一次接触后的第 14 天和第 35 天，通过标准程序评估精子形态。 加巴喷丁和苯妥英未引起精子形态的显著变化。结果表明，苯妥英和加巴喷丁不是雄性生殖细胞诱变剂，似乎不会对男性生育力产生不利影响。
