Bigalke B, Lindemann S, Gawaz M
Medizinische Klinik III, Eberhard Karls Universität Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen.
Hamostaseologie. 2007 Dec;27(5):338-43.
Platelets play a critical role in formation of coronary thrombosis. An enhanced systemic platelet activation plays a significant role in the acute coronary syndrome. Despite better interventional techniques and better concomitant pharmacological therapy, the degree of platelet activation contributes significantly to prognosis and postinterventional event rate. Residual platelet activation after intervention is often associated with an enhanced initial platelet activation prior interventional treatment. An effective antiplatelet therapy is of utmost importance for the acute therapy and for secondary prevention in patients undergoing coronary interventions or with acute coronary syndrome. The efficacy of the antithrombotic therapy determines the long term prognosis in these patients.
血小板在冠状动脉血栓形成中起关键作用。全身性血小板活化增强在急性冠状动脉综合征中起重要作用。尽管有更好的介入技术和更有效的伴随药物治疗，但血小板活化程度对预后和介入后事件发生率仍有显著影响。介入后残留的血小板活化通常与介入治疗前初始血小板活化增强有关。有效的抗血小板治疗对于接受冠状动脉介入治疗或患有急性冠状动脉综合征的患者的急性治疗和二级预防至关重要。抗血栓治疗的疗效决定了这些患者的长期预后。
