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[通过局部手术翻修和造永久性瘘管来保留髋关节假体:老年多病症患者假体周围感染姑息治疗的一种选择?]

[Preservation of hip prosthesis with local surgical revision and creation of a fistula persistens : an option for palliative treatment of periprosthetic infection in old, polymorbid patients?].

作者信息

Tiemann A H, Homagk L, Diefenbeck M, Mückley T, Hofmann G O

机构信息

Abteilung für Septische und Rekonstruktive Chirurgie, Klinik für Unfall- und Wiederherstellungschirurgie,BG-Kliniken Bergmannstrost, Merseburger Strasse 165, 06112, Halle Saale, Deutschland.

出版信息

Unfallchirurg. 2007 Dec;110(12):1021-9. doi: 10.1007/s00113-007-1367-7.

Abstract

BACKGROUND

The number of implanted hip prostheses is increasing constantly. At the same time the patients are becoming older and older. Thus, also patients with periprosthetic infections are older and therefore sicker. Uniform guidelines for the treatment of infected arthroplasties are controversial. Empirical studies show that the explantation of the original prosthesis and implantation of a revision may be the option with the greatest chance of success. These very aggressive procedures may overburden the old, polymorbid patient. The aim of this study was to ascertain whether or not keeping the hip prosthesis in combination with local debridement, formation of a permanent fistula and long-term administration of antibiotics is a possible option for the treatment of infected hip prostheses in old and polymorbid patients.

PATIENTS

Between 01.01.2004 and 28.01.2007, 12 patients with periprosthetic infection after hip arthroplasty (PIH) were treated. Their average age was 79.8 years. Eleven patients were rated ASA III preoperatively. The prostheses were on average 23.8 weeks old when the first signs of infection occurred. In 10 cases the infection was caused by Staphylococcus (MRSA 3x). The main comorbidities were hypertension, diabetes, coronary heart disease and thyroid malfunction.

RESULTS

After a mean 8.83 months, six patients were deceased (average age 85.50 years). In five of the remaining six patients the fistula worked without any problem. In one case the fistula was occluded. None of the patients showed any sign of acute infection. All were able to walk with full weight-bearing on the affected hip.

CONCLUSION

Restricting the indication to old, polymorbid patients, preservation of the arthroplasty in combination with local surgical debridement, permanent fistula and long-term systemic administration of antibiotics seems to be an alternative to explantation of the prosthesis with consecutive revision arthroplasty or resection arthroplasty.

摘要

背景

髋关节假体植入数量持续增加。与此同时,患者年龄越来越大。因此,假体周围感染的患者年龄更大,病情也更严重。关于感染性关节置换治疗的统一指南存在争议。实证研究表明,取出原假体并植入翻修假体可能是最有可能成功的选择。这些极具侵入性的手术可能会使年老、患有多种疾病的患者不堪重负。本研究的目的是确定保留髋关节假体并结合局部清创、形成永久性瘘管以及长期使用抗生素是否是治疗老年和患有多种疾病患者感染性髋关节假体的一种可行选择。

患者

2004年1月1日至2007年1月28日期间,对12例髋关节置换术后假体周围感染(PIH)患者进行了治疗。他们的平均年龄为79.8岁。11例患者术前被评为ASA III级。感染的最初迹象出现时,假体平均使用了23.8周。10例感染由葡萄球菌引起(耐甲氧西林金黄色葡萄球菌3例)。主要合并症为高血压、糖尿病、冠心病和甲状腺功能障碍。

结果

平均8.83个月后,6例患者死亡(平均年龄85.50岁)。其余6例患者中有5例瘘管通畅,无任何问题。1例瘘管堵塞。所有患者均无急性感染迹象。所有人患侧髋关节均能完全负重行走。

结论

对于老年、患有多种疾病的患者,限制手术适应症,保留关节置换并结合局部手术清创、永久性瘘管和长期全身使用抗生素似乎是假体取出并连续进行翻修关节置换术或切除关节成形术的一种替代方法。

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