Chehade Mirna
Pediatric Gastroenterology and Nutrition, Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Gastrointest Endosc Clin N Am. 2008 Jan;18(1):145-56; x. doi: 10.1016/j.giec.2007.09.013.
Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus characterized by eosinophilic infiltration of the esophageal epithelium. EE is a relatively new disease from clinical and research standpoints. A recent surge in basic and translational studies has emerged to understand its pathogenesis since its recognition as a separate entity from acid-induced gastroesophageal reflux disease in 1995. Our understanding of this disease is still limited, however. In this article, available evidence from translational studies on EE is discussed, focusing on the allergic nature of the disease and highlighting the role of various inflammatory cells found in the esophagus of patients who have EE. Esophageal remodeling in EE is also discussed.
嗜酸性粒细胞性食管炎（EE）是一种食管炎症性疾病，其特征为食管上皮嗜酸性粒细胞浸润。从临床和研究角度来看，EE是一种相对较新的疾病。自1995年被确认为与酸诱导的胃食管反流病不同的独立疾病以来，基础研究和转化研究最近激增，以了解其发病机制。然而，我们对这种疾病的认识仍然有限。在本文中，将讨论来自EE转化研究的现有证据，重点关注该疾病的过敏性本质，并强调在EE患者食管中发现的各种炎症细胞的作用。还将讨论EE中的食管重塑。
