NQO1和GSTP1基因多态性与多发性骨髓瘤风险之间不存在关联。
Lack of association of NQO1 and GSTP1 polymorphisms with multiple myeloma risk.
作者信息
Maggini Valentina, Buda Gabriele, Galimberti Sara, Martino Alessandro, Orciuolo Enrico, Morabito Fortunato, Bono Roberto, Barale Roberto, Petrini Mario, Rossi Anna Maria
机构信息
Department of Biology, Pisa University, Pisa, Italy.
出版信息
Leuk Res. 2008 Jun;32(6):988-90. doi: 10.1016/j.leukres.2007.10.008. Epub 2007 Dec 3.
Individual differences in xenobiotica metabolising capacity can influence susceptibility to multiple myeloma. NQO1 and GSTT1 polymorphisms were recently reported as risk factors for multiple myeloma and GSTP1 genotype was found to be a prognostic marker for therapy outcome in multiple myeloma. The aim of this study was to determine whether specific defective alleles of NQO1 (P187S) and GSTP1 (I105V) genes are associated with increased risk of multiple myeloma. Individual genotypes of 128 patients affected by multiple myeloma and 245 healthy controls were determined and our results do not support any major role of NQO1 or GSTP1 polymorphisms in multiple myeloma pathogenesis.
异生物素代谢能力的个体差异会影响多发性骨髓瘤的易感性。最近有报道称，NQO1和GSTT1基因多态性是多发性骨髓瘤的危险因素，并且发现GSTP1基因型是多发性骨髓瘤治疗结果的一个预后标志物。本研究的目的是确定NQO1基因（P187S）和GSTP1基因（I105V）的特定缺陷等位基因是否与多发性骨髓瘤风险增加相关。我们确定了128例多发性骨髓瘤患者和245例健康对照的个体基因型，结果并不支持NQO1或GSTP1基因多态性在多发性骨髓瘤发病机制中起任何主要作用。
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