Apoptosis and the insulin-like growth factor family in the developing olfactory epithelium.

Vertebrate olfactory receptor neurons (ORN) are unique in that they are continually replaced throughout life. They die by apoptosis under physiological conditions at all stages during the life cycle, and apoptotic ORN are replaced by their progenitor cells. Apoptosis is linked with neurogenesis, of which pathway is regulated by a number of growth factors and neurotrophic factors. Members of the insulin-like growth factor (IGF) family have an anti-apoptotic effect on ORN, in addition to their ability to promote the proliferation, differentiation, and survival of these neurons. Expression of IGF and related molecules at both mRNA and protein levels in the olfactory epithelium have been reported. In this review article, we focus on apoptosis, IGF, and their related molecules in the developing olfactory epithelium.