Vacek V
II. Infekcní klinika 3, lékarské fakulty, Univerzity Karlovy a fakultní nemocnice, Praha.
Cas Lek Cesk. 1991 Dec 27;130(26):715-22.
A survey of microbiological and pharmacological properties of, of clinical experience with and of untoward reactions of lincomycin and clindamycin has been presented. Both antibiotics are active against gram-positive aerobic and many anaerobic bacteria. As to anti-anaerobic activity, clindamycin is superior to lincomycin. Consequently, anaerobic infections are main indication for clindamycin in clinical practice. On the other hand, lincomycin shows excellent penetration into body fluids and tissues and its dosage can be adapted to actual clinical situation in a very wide range. Recently, combinations of clindamycin with other drugs have proved effective in the treatment of falciparum malaria as well as of acute toxoplasmosis and Pneumocystis pneumonia in AIDS patients. Both lincomycin and clindamycin play still an important role in chemotherapy of infections.
本文综述了林可霉素和克林霉素的微生物学和药理学特性、临床应用经验及不良反应。这两种抗生素对革兰氏阳性需氧菌和许多厌氧菌均有活性。在抗厌氧菌活性方面，克林霉素优于林可霉素。因此，厌氧菌感染是克林霉素在临床实践中的主要适应证。另一方面，林可霉素在体液和组织中具有良好的穿透力，其剂量可在很宽的范围内根据实际临床情况进行调整。最近，已证明克林霉素与其他药物联合使用对治疗恶性疟原虫疟疾以及艾滋病患者的急性弓形虫病和肺孢子菌肺炎有效。林可霉素和克林霉素在感染化疗中仍发挥着重要作用。
