Ramasubbu Kumudha, Mann Douglas L, Deswal Anita
Micheal E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Cardiol Clin. 2007 Nov;25(4):573-80; vi-vii. doi: 10.1016/j.ccl.2007.09.003.
Activation of the renin-angiotensin system (RAS) plays an important role in the pathogenesis of heart failure. Thus, strategies for the treatment of heart failure have focused on agents that block the RAS. More recently, the role of angiotensin receptor blockers (ARBs) in heart failure therapy has been better defined. This article examines the rationale and role of ARBs in the treatment of patients with heart failure on the basis of evidence from clinical trials.
肾素-血管紧张素系统（RAS）的激活在心力衰竭的发病机制中起重要作用。因此，心力衰竭的治疗策略主要集中在阻断RAS的药物上。最近，血管紧张素受体阻滞剂（ARB）在心力衰竭治疗中的作用已得到更明确的界定。本文根据临床试验证据探讨了ARB在心力衰竭患者治疗中的基本原理和作用。
