Mellor Andrew L, Munn David H
Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA.
Nat Rev Immunol. 2008 Jan;8(1):74-80. doi: 10.1038/nri2233.
Natural regulatory mechanisms prevent inappropriate immune activation to self and innocuous foreign antigens. Here, we adapt the notion of immune privilege, which was originally applied to transplanted tissues, to consider how antigenic tumour cells and chronic pathogens might exploit natural regulatory mechanisms to become non-immunogenic. This conceptual approach reveals new mechanistic perspectives that may help to explain the paradoxical persistence of tumours and chronic pathogens, and suggests new opportunities to improve immunotherapy to treat these chronic inflammatory diseases.
天然调节机制可防止对自身和无害外来抗原的不适当免疫激活。在此，我们采用最初应用于移植组织的免疫豁免概念，来探讨抗原性肿瘤细胞和慢性病原体如何利用天然调节机制变得具有非免疫原性。这种概念性方法揭示了新的机制观点，可能有助于解释肿瘤和慢性病原体矛盾的持续存在，并为改善免疫疗法以治疗这些慢性炎症性疾病提供了新的机会。
