Deng Chao, Han Mei, Huang Xu-Feng
School of Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.
Neurosci Bull. 2007 Nov;23(6):341-7. doi: 10.1007/s12264-007-0051-9.
In recent years, abnormal changes in the endocannabinoid system have been found in schizophrenia. The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. In this study, we investigated the binding density of cannabinoid CB1 receptors in the STG of schizophrenia patients compared to control subjects.
Quantitative autoradiography was used to investigate the binding densities of [(3)H]SR141716A (a selective antagonist) and [(3)H]CP-55940 (an agonist) to the CB1 receptors in the STG. Post-mortem brain tissue was obtained from the NSW Tissue Resource Centre (Australia).
Contrasting to previous findings in the alterations of CB1 receptor densities in the prefrontal, anterior and posterior cingulate cortex of schizophrenia, which were suggested to be associated to impairment of cognition function, no significant difference was found between the schizophrenia and control cases in both [(3)H]SR141716A and [(3)H]CP-55940 binding.
We suggest that CB1 receptors in the STG are not involved in the pathology of schizophrenia and the auditory hallucination symptom of this disease.
近年来，已发现精神分裂症患者的内源性大麻素系统存在异常变化。颞上回（STG）与精神分裂症的病理生理学密切相关，尤其是在幻听方面。在本研究中，我们调查了精神分裂症患者与对照受试者相比，颞上回中大麻素CB1受体的结合密度。
采用定量放射自显影术研究[(3)H]SR141716A（一种选择性拮抗剂）和[(3)H]CP - 55940（一种激动剂）与颞上回中CB1受体的结合密度。死后脑组织取自新南威尔士州组织资源中心（澳大利亚）。
与先前在精神分裂症患者前额叶、前扣带回和后扣带回皮质中CB1受体密度改变的研究结果相反（这些改变被认为与认知功能损害有关），在[(3)H]SR141716A和[(3)H]CP - 55940结合方面，精神分裂症患者与对照组之间未发现显著差异。
我们认为颞上回中的CB1受体不参与精神分裂症的病理过程以及该疾病的幻听症状。
