ATP敏感性钾通道：在帕金森病中的新潜在作用。
ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.
作者信息
Zeng Jie, Wang Gang, Chen Sheng-Di
机构信息
Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
出版信息
Neurosci Bull. 2007 Nov;23(6):370-6. doi: 10.1007/s12264-007-0055-5.
Abstract
The ATP-sensitive potassium (K(ATP)) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. The aim of this review is to get insight into the novel roles of K(ATP) channels in Parkinson's disease (PD), with consideration of the specificities K(ATP) channels in the central nervous system (CNS), such as the control of neuronal excitability, action potential, mitochondrial function and neurotransmitter release.
摘要
ATP敏感性钾（K(ATP)）通道广泛分布于多种组织（如血管平滑肌、心肌细胞和胰腺），因其具有血管舒张、心肌缺血保护和胰岛素分泌等特性而广为人知。本综述的目的是深入了解K(ATP)通道在帕金森病（PD）中的新作用，同时考虑到K(ATP)通道在中枢神经系统（CNS）中的特异性，如对神经元兴奋性、动作电位、线粒体功能和神经递质释放的控制。
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