Minton O, Stone P
Macmillan reader in palliative medicine, Division of mental health, St. Georges University of London, 6th floor Hunter Wing, Cranmer Terrace, London, SW17 ORE, UK.
Breast Cancer Res Treat. 2008 Nov;112(1):5-13. doi: 10.1007/s10549-007-9831-1. Epub 2007 Dec 7.
There is some debate in the literature as to whether fatigue persists in the long term in women who have completed adjuvant breast cancer treatment.
A systematic review was conducted in order to characterise and quantify the phenomenon of post treatment fatigue (PTF).
There was a wide variation in the measures of fatigue used, duration of follow-up and type of comparison made. Overall 18 studies were identified with a follow-up period of between 4 months and 10 years. Fourteen studies demonstrated the presence of continued PTF and/or differences in fatigue levels compared to a reference population up to 5 years after treatment. One short-term study reported no increase in fatigue at 4 months. Three studies (with an average follow up period of longer than 5 years) did not identify overall quality of life differences in breast cancer survivors when compared with a reference population. However there were significant differences in measures of physical functioning and mental fatigue.
The authors conclude that there is good evidence of PTF occurring up to 5 years after completion of adjuvant therapy.
关于完成辅助性乳腺癌治疗的女性长期是否存在疲劳，文献中有一些争议。
进行了一项系统评价，以描述和量化治疗后疲劳（PTF）现象。
所使用的疲劳测量方法、随访持续时间和所做比较类型存在很大差异。总共确定了18项研究，随访期在4个月至10年之间。14项研究表明，与参考人群相比，治疗后长达5年存在持续的PTF和/或疲劳水平差异。一项短期研究报告称，4个月时疲劳没有增加。三项研究（平均随访期超过5年）在将乳腺癌幸存者与参考人群比较时，未发现总体生活质量差异。然而，在身体功能和精神疲劳测量方面存在显著差异。
作者得出结论，有充分证据表明辅助治疗完成后长达5年存在PTF。
