Burns T, Knapp M, Catty J, Healey A, Henderson J, Watt H, Wright C
Department of Community Psychiatry, St George's Hospital Medical School, London, UK.
Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150.
This review investigates the effectiveness of 'home treatment' for mental health problems in terms of hospitalisation and cost-effectiveness. For the purposes of this review, 'home treatment' is defined as a service that enables the patient to be treated outside hospital as far as possible and remain in their usual place of residence. METHODS - SYSTEMATIC LITERATURE SEARCH: 'Home treatment' excluded studies focused on day, residential and foster care. The review was based on Cochrane methodology, but non-randomised studies were included if they compared two services; these were only analysed if they provided evidence of the groups' baseline clinical comparability. METHODS - REVIEW OF ECONOMIC EVALUATIONS: Economic evaluations among the studies found were reviewed against established criteria. METHODS - IDENTIFICATION OF SERVICE COMPONENTS: A three-round Delphi exercise ascertained the degree of consensus among expert psychiatrists concerning the important components of community-based services that enable them to treat patients outside hospital. The identified components were used to construct the follow-up questionnaire. METHODS - FOLLOW-UP OF AUTHORS: As a supplement to the information available in the papers, authors of all the studies were followed up for data on service components, sustainability of programmes and service utilisation. METHODS - DATA ANALYSIS: The outcome measure was mean days in hospital per patient per month over the follow-up period. (1) Comparative analysis - compared experimental to control services. It analysed all studies with available data, divided into 'inpatient-control' and 'community-control' studies, and tested for associations between service components and difference in hospital days. (2) Experimental services analysis - analysed only experimental service data and tested for associations between service components and hospital days. RESULTS - SYSTEMATIC LITERATURE SEARCH: A total of 91 studies were found, conducted over a 30-year period. The majority (87) focused on people with psychotic disorders. RESULTS - REVIEW OF ECONOMIC EVALUATIONS: Only 22 studies included economic evaluations. They provided little conclusive evidence about cost-effectiveness because of problems with the heterogeneity of services, sample size, outcome measures and quality of analysis. RESULTS - DELPHI EXERCISE: In all, 16 items were rated as 'essential', falling into six categories: home environment; skill-mix; psychiatrist involvement; service management; caseload size; and health/social care integration. There was consensus that caseloads under 25 and flexible working hours over 7 days were important, but little support for caseloads under 15 or for 24-hour services, and consensus that home visiting was essential, but not on teams being 'explicitly dedicated' to home treatment. RESULTS - RESPONSE TO FOLLOW-UP: A total of 60% of authors responded, supplying data on service components and hospital days in most cases. Other service utilisation data were far less readily available. RESULTS - SERVICE CHARACTERISATION AND CLASSIFICATION: The services were homogeneous in terms of 'home treatment function' but fairly heterogeneous in terms of other components. There was some evidence for a group of services that were multidisciplinary, had psychiatrists as integrated team members, had smaller caseloads, visited patients at home regularly and took responsibility for both health and social care. This was not a cohesive group, however. RESULTS - SUSTAINABILITY OF SERVICES: The sustainability of home treatment services was modest: less than half the services whose authors responded were still identifiable. Services were more likely to be operational if the study had found them to reduce hospitalisation significantly. RESULTS - META-ANALYSIS: Meta-analysis with heterogeneous studies is problematic. The evidence base for the effectiveness of services identifiable as 'home treatment' was not strong. Within the 'inpatient-control' study group, the mean reduction in hospitalisation was 5 days per patient per month (for 1-year studies only). No statistical significance could be measured for this result. For 'community-control' studies, the reduction in hospitalisation was negligible. Moreover, the heterogeneity of control services, the wide range of outcome measures and the limited availability of data might have confounded the analysis. Regularly visiting at home and dual responsibility for health and social care were associated with reduced hospitalisation. Evidence for other components was inconclusive. Few conclusions could be drawn from the analysis of service utilisation data. RESULTS - LOCATION: Studies were predominately from the USA and UK, more of them being from the USA. North American studies found a reduction in hospitalisation of 1 day per patient per month more than European studies. North American and European services differed on some service components, but this was unlikely to account for this finding, particularly as no difference was found in their experimental service results. CONCLUSIONS - STATE OF RESEARCH: There is a clear need for further studies, particularly in the UK. The benefit of home treatment over admission in terms of days in hospital was clear, but over other community-based alternatives was inconclusive. CONCLUSIONS - NON-RANDOMISED STUDIES: Difficulties in systematically searching for non-randomised studies may have contributed to the smaller number of such studies found (35, compared with 56 randomised controlled trials). This imbalance was compounded by a relatively poor response rate from non-randomised controlled trial authors. Including them in the analysis had little effect. CONCLUSIONS - LIMITATIONS OF THIS REVIEW: A broad area was reviewed in order to avoid the problem of analysing by service label. While reviews of narrower areas may risk implying a homogeneity of the services that is unwarranted, the current strategy has the drawback that the studies cover a range of heterogeneous services. The poor definition of control services, however, is ubiquitous in this field, however reviewed areas are defined. Inclusion of mean data for which no standard deviations were available was problematic in that it prevented measuring the significance of the main findings. The lack of availability of this data, however, is an important finding, demonstrating the difficulty in seeking certainty in this area. Only days in hospital and cost-effectiveness were analysed here. The range and lack of uniformity of measures used in this field made meta-analysis of other outcomes impossible. It should be noted, however, that the findings pertain to these aspects alone. The Delphi exercise reported here was limited in being conducted only with psychiatrists, rather than a multidisciplinary panel. Its findings were used as a framework for the follow-up and analysis. Their possible bias should be borne in mind when considering them as findings in themselves. CONCLUSIONS - IMPLICATIONS FOR CLINICIANS: The evidence base for home treatment compared with other community-based services is not strong, although it does show that home treatment reduces days spent in hospital compared with inpatient treatment. There is evidence that visiting patients at home regularly and taking responsibility for both health and social care each reduce days in hospital. CONCLUSIONS - IMPLICATIONS FOR CONSUMERS: Services that visit patients at home regularly and those that take responsibility for both health and social care are likely to reduce time spent in hospital. Psychiatrists surveyed in this review also considered support for carers to be essential. The evidence from this review, however, was that few services currently have protocols for meeting carers' needs. CONCLUSIONS - RECOMMENDATIONS FOR RESEARCH AND COMMISSIONERS: A centrally coordinated research strategy, with attention to study design, is recommended. Studies should include economic evaluations that report health and social service utilisation. Service components should be collected and reported for both experimental and control services. Studies should be designed with adequate power and longer durations of follow-up and use comparable outcome measures to facilitate meta-analysis. Research protocols should be adhered to throughout the studies. It may be advisable that independent researchers conduct studies in future. It is no longer recommended that home treatment be tested against inpatient care, or that small, localised studies replicate existing, more highly powered studies.
本综述从住院治疗情况和成本效益方面,研究了“居家治疗”对心理健康问题的有效性。在本综述中,“居家治疗”被定义为一种尽可能让患者在院外接受治疗并留在其常住地的服务。方法——系统文献检索:“居家治疗”排除了聚焦日间护理、寄宿护理和寄养护理的研究。本综述基于Cochrane方法,但如果非随机研究比较了两种服务,则将其纳入;只有当这些研究提供了两组基线临床可比性的证据时,才会对其进行分析。方法——经济评估综述:根据既定标准对所发现研究中的经济评估进行综述。方法——服务组成部分识别:通过三轮德尔菲法确定专家精神科医生对基于社区的服务中能让他们在院外治疗患者的重要组成部分的共识程度。所确定的组成部分用于构建后续调查问卷。方法——作者随访:作为论文中可用信息的补充,对所有研究的作者进行随访,以获取有关服务组成部分、项目可持续性和服务利用情况的数据。方法——数据分析:结果指标是随访期间每位患者每月的平均住院天数。(1)比较分析——将实验性服务与对照服务进行比较。分析了所有有可用数据的研究,分为“住院对照”和“社区对照”研究,并检验服务组成部分与住院天数差异之间的关联。(2)实验性服务分析——仅分析实验性服务数据,并检验服务组成部分与住院天数之间的关联。结果——系统文献检索:共找到91项研究,历时30年。大多数研究(87项)聚焦于患有精神障碍的人群。结果——经济评估综述:只有22项研究包括经济评估。由于服务异质性、样本量、结果指标和分析质量等问题,它们几乎没有提供关于成本效益的确凿证据。结果——德尔菲法:总共16项被评为“必不可少”,分为六类:家庭环境;技能组合;精神科医生参与度;服务管理;工作量规模;以及健康/社会护理整合。大家一致认为工作量低于25且7天内灵活的工作时间很重要,但对于工作量低于15或24小时服务支持较少,并且一致认为家访必不可少,但对于专门“致力于”居家治疗的团队则没有达成共识。结果——随访回复:共有60%的作者回复,大多数情况下提供了关于服务组成部分和住院天数的数据。其他服务利用数据则很难获得。结果——服务特征与分类:这些服务在“居家治疗功能”方面具有同质性,但在其他组成部分方面差异较大。有证据表明,有一组服务是多学科的,精神科医生是综合团队成员,工作量较小,定期家访并负责健康和社会护理。然而,这并不是一个紧密的群体。结果——服务可持续性:居家治疗服务的可持续性一般:回复的作者所提到的服务中,不到一半仍然可以识别。如果研究发现某项服务能显著减少住院率,那么该服务更有可能继续运营。结果——荟萃分析:对异质性研究进行荟萃分析存在问题。被确定为“居家治疗”的服务有效性的证据基础并不牢固。在“住院对照”研究组中,每位患者每月的平均住院天数减少了5天(仅针对为期1年的研究)。该结果无统计学意义。对于“社区对照”研究,住院天数的减少可以忽略不计。此外,对照服务的异质性、结果指标的广泛范围以及数据的有限可用性可能使分析产生混淆。定期家访以及对健康和社会护理的双重责任与住院天数减少相关。其他组成部分的证据尚无定论。从服务利用数据分析中几乎无法得出结论。结果——研究地点:研究主要来自美国和英国,其中更多来自美国。北美研究发现每位患者每月的住院天数比欧洲研究减少1天。北美和欧洲的服务在一些服务组成部分上存在差异,但这不太可能解释这一发现,特别是因为它们的实验性服务结果没有差异。结论——研究现状:显然需要进一步研究,尤其是在英国。居家治疗在住院天数方面优于住院治疗的益处是明显的,但与其他基于社区的替代方案相比则尚无定论。结论——非随机研究:系统搜索非随机研究存在困难,这可能导致此类研究数量较少(35项,而随机对照试验有56项)。这种不平衡因非随机对照试验作者相对较低的回复率而加剧。将它们纳入分析影响不大。结论——本综述的局限性:为避免按服务标签进行分析的问题,对一个广泛领域进行了综述。虽然对较窄领域的综述可能存在暗示服务同质性而无根据的风险,但当前策略的缺点是研究涵盖了一系列异质性服务。然而,对照服务定义不明确在该领域普遍存在,无论综述领域如何定义。纳入没有标准差的均值数据存在问题,因为这无法衡量主要发现的显著性。然而,缺乏这些数据本身就是一个重要发现,表明在该领域寻求确定性存在困难。这里仅分析了住院天数和成本效益。该领域使用的测量方法范围广泛且缺乏一致性,使得对其他结果进行荟萃分析变得不可能。然而,应注意的是,这些发现仅适用于这些方面。这里报告的德尔菲法仅由精神科医生进行,而非多学科小组,存在局限性。其结果被用作随访和分析的框架。在将其视为自身结果时,应牢记其可能存在的偏差。结论——对临床医生的启示:与其他基于社区的服务相比,居家治疗的证据基础并不牢固,尽管它确实表明与住院治疗相比,居家治疗减少了住院天数。有证据表明,定期家访以及对健康和社会护理负责均可减少住院天数。结论——对消费者的启示:定期家访的服务以及对健康和社会护理负责的服务可能会减少住院时间。本综述中接受调查的精神科医生也认为对护理人员的支持至关重要。然而,本综述的证据表明,目前很少有服务制定了满足护理人员需求的方案。结论——对研究和委托方的建议:建议制定一项集中协调的研究策略,并关注研究设计。研究应包括报告健康和社会服务利用情况的经济评估。应收集并报告实验性服务和对照服务的服务组成部分。研究应设计有足够的效力和更长的随访期,并使用可比的结果指标以促进荟萃分析。在整个研究过程中应遵循研究方案。未来可能建议由独立研究人员进行研究。不再建议将居家治疗与住院护理进行对比测试,也不建议小规模的局部研究重复现有的、更具效力的研究。