Godukhin O V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Sep-Oct;57(5):541-52.
In this review, the role of pro-inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and anti-inflammatory cytokine, IL-10, in the seizure activity development is analyzed. In recent years, there has been increasing evidence that the transformation of normal pattern of neuronal activity to paroxysmal one is associated with the increased production of these cytokines in the brain. However, the present results indicate that expressions of IL-1, TNF-alpha and IL-10 in the brain are associated with cell injury rather than with seizures per se. These findings suggest that, in response to seizures, these cytokines cause both neuroprotective or neurodegenerative effects and, as a consequence of these effects, the further facilitation or depression of seizure activity.
在本综述中，分析了促炎细胞因子白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）以及抗炎细胞因子IL-10在癫痫活动发展中的作用。近年来，越来越多的证据表明，神经元活动的正常模式向阵发性模式的转变与大脑中这些细胞因子的产生增加有关。然而，目前的结果表明，大脑中IL-1、TNF-α和IL-10的表达与细胞损伤有关，而不是与癫痫本身有关。这些发现表明，在癫痫发作时，这些细胞因子会产生神经保护或神经退行性作用，并且由于这些作用，会进一步促进或抑制癫痫活动。
