Hidiroglou M, Karpinski K
Agriculture Canada Animal Research Centre, Ottawa, Ontario.
Int J Vitam Nutr Res. 1991;61(4):298-303.
Two groups of five wethers each (40-50 kg body weight) were used. All were dosed intramuscularly (gluteus) with D-alpha-tocopherol. Five randomly selected sheep received a dose of 900 IU while the other five received 1800 IU. Doses were administered at 0, 6 and 14 days and at 7 day intervals for an additional 6 weeks. Plasma and liver samples were taken at various times. Single exponential equations provided good characterization of the multiple dose trough D-alpha-tocopherol concentrations in plasma and liver. There was a significant dose-response relationship for maximum concentration, area under the plasma curve and levels of hepatic alpha-tocopherol. These levels were proportional to the D-alpha-tocopherol dose given.
使用了两组，每组五只阉羊（体重40 - 50千克）。所有阉羊均通过肌肉注射（臀肌）给予D-α-生育酚。随机选择五只绵羊接受900国际单位的剂量，而另外五只接受1800国际单位的剂量。在第0、6和14天给药，之后每隔7天给药一次，持续6周。在不同时间采集血浆和肝脏样本。单指数方程很好地描述了血浆和肝脏中多次给药后谷值D-α-生育酚浓度。最大浓度、血浆曲线下面积和肝脏α-生育酚水平存在显著的剂量反应关系。这些水平与给予的D-α-生育酚剂量成正比。
