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带有二炔基侧链的核苷和寡核苷酸：在DNA及其组成成分上进行的惠斯根-夏普莱斯环加成“点击反应”

Nucleosides and oligonucleotides with diynyl side chains: the huisgen-sharpless cycloaddition "click reaction" performed on DNA and their constituents.

作者信息

Seela Frank, Sirivolu Venkata Ramana

机构信息

Laboratorium für Organische und Bioorganische Chemie, Universität Osnabrück, Barbarastrasse 7, 49069 Osnabrück, Germany.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):597-601. doi: 10.1080/15257770701490308.

DOI:10.1080/15257770701490308
PMID:18066862
Abstract

Phosphoramidite building blocks related to the four canonical DNA constituents and oligonucleotides with octadiynyl side chains (5b-8b) or dipropargyl ether residues (5c) were synthesized. Nucleosides and oligonucleotides were functionalized at the terminal triple bonds employing the Huisgen-Sharpless cycloaddition "click reaction."

摘要

合成了与四种标准DNA组分相关的亚磷酰胺砌块以及带有辛二炔侧链（5b - 8b）或二炔丙基醚残基（5c）的寡核苷酸。利用惠斯根-夏普莱斯环加成“点击反应”在末端三键处对核苷和寡核苷酸进行功能化修饰。

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