Jessen H J, Tonn V, Meier C
Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz, Hamburg, Germany.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):827-30. doi: 10.1080/15257770701503886.
A new synthesis for cycloSal-pronucleotides bearing enzymatically cleavable triggers is presented. This trigger is introduced to trap the pronucleotide inside cells. The general concept and hydrolysis data in different media are discussed.
本文介绍了一种带有可酶切触发基团的环Sal-前体核苷酸的新合成方法。引入该触发基团以将前体核苷酸捕获在细胞内。讨论了其总体概念以及在不同介质中的水解数据。
