新型环孢菌素 - 核苷膦酸酯前药。
New cycloAmb-nucleoside phosphonate prodrugs.
作者信息
Görbig U, Balzarini J, Meier C
机构信息
Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Hamburg, Germany.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):831-4. doi: 10.1080/15257770701503894.
PMID:18066909
Abstract
cycloSal- and cycloAmb-nucleoside phosphonate prodrugs of PMEA were synthesized and characterized. Each of these compounds showed different disadvantages in hydrolysis. Thus, a new series of cycloAminobenzyl(cycloAmb)-PMEA prodrugs was synthezised and studied with regard to their hydrolysis properties and biological activity.
摘要
合成并表征了PMEA的环Sal-和环Amb-核苷膦酸酯前药。这些化合物中的每一种在水解方面都表现出不同的缺点。因此，合成了一系列新的环氨基苄基（环Amb）-PMEA前药，并对其水解性质和生物活性进行了研究。
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