Rendon D A
Laboratory of Biophysics, Faculty of Sciences, National University of Colombia-Medellin Branch, Medellin, Colombia.
Int J Toxicol. 2007 Nov-Dec;26(6):571-5. doi: 10.1080/10915810701728698.
The bioenergetics of cardiac, liver, and kidney mitochondria after 9-day treatment regimen with benzonidazole was studied in rats. The drug was given by oral gavage to adult male Sprague-Dawley rats for 9 consecutive days (100 mg benzonidazole/kg body weight as daily dose). The assayed mitochondrial bioenergetic parameters were the state 4, state 3, respiratory control, efficiency of oxidative phosphorylation, and the activity of the mitochondrial ATP synthase. The results showed that mitochondrial parameters were not altered statistically after in cardiac and kidney mitochondria, but respiratory control in liver mitochondria was statistically increased with benzonidazole treatment. This change was likely due to a slight decrease in state 4 bioenergy metabolism. These results indicate that 9-day benzonidazole treatment regimen had no negative effect on cardiac, liver, and kidney mitochondrial energy metabolism but increased respiratory control in rat liver mitochondria.
在大鼠中研究了用苯并硝唑进行9天治疗方案后心脏、肝脏和肾脏线粒体的生物能量学。将该药物经口灌胃给予成年雄性Sprague-Dawley大鼠，连续9天（每日剂量为100mg苯并硝唑/ kg体重）。所测定的线粒体生物能量学参数为状态4、状态3、呼吸控制、氧化磷酸化效率以及线粒体ATP合酶的活性。结果表明，心脏和肾脏线粒体的线粒体参数在统计学上没有改变，但苯并硝唑治疗后肝脏线粒体的呼吸控制在统计学上有所增加。这种变化可能是由于状态4生物能量代谢略有下降。这些结果表明，9天的苯并硝唑治疗方案对心脏、肝脏和肾脏线粒体能量代谢没有负面影响，但增加了大鼠肝脏线粒体的呼吸控制。
