[Th17细胞的研究进展]

[Research progress on Th17 cells].

作者信息

Zhang Wei, Luo Fang-jun, Zhou Jiao-jiao

机构信息

College of Medicine, Zhejiang University, Hangzhou 310058, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Nov;36(6):620-5. doi: 10.3785/j.issn.1008-9292.2007.06.018.

DOI:10.3785/j.issn.1008-9292.2007.06.018

PMID:18067239

Abstract

Th17(T helper 17 cell), a newly discovered subset of T cells is associated with IL-23 and characterized by production of IL-17, the functions of which are distinct from those of Th1, Th2 and Treg subsets. The development of Th17 cells can be promoted by TGF-beta1, IL-6, and IL-23; but inhibited by IFN-gamma, IL-4 and Socs3. It is clear that Th17 cells have protective effects on body by facilitating the pro-inflammatory responses. On the other hand, the role of Th17 cells in the pathophysiology of autoimmune diseases has been described.

摘要

辅助性T细胞17（Th17）是新发现的T细胞亚群，与白细胞介素23（IL-23）相关，其特征是产生白细胞介素17（IL-17），其功能不同于Th1、Th2和调节性T细胞（Treg）亚群。转化生长因子β1（TGF-β1）、白细胞介素6（IL-6）和白细胞介素23可促进Th17细胞的发育；但会受到干扰素γ（IFN-γ）、白细胞介素4（IL-4）和细胞因子信号转导抑制因子3（Socs3）的抑制。很明显，Th17细胞通过促进促炎反应对机体具有保护作用。另一方面，Th17细胞在自身免疫性疾病病理生理学中的作用也已有描述。