Wang Cun, Zhou Zong-guang, Yu Yong-yang, Li Yuan, Yang Lie, Cheng Zhong, Lei Wen-zhang
Department of General Surgery III, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Wai Ke Za Zhi. 2007 Sep 1;45(17):1160-3.
To study lateral pelvic metastasis and micrometastasis of low rectal cancer and elucidate their prognostic value.
Whole-mount slice and tissue microarray of dissected lateral pelvic specimen from 67 cases of low rectal cancer were examined, and the included cases were followed up.
Twelve specimens were diagnosed as lateral metastasis, while another 10 were proved to bear micrometastasis. Most of the involved metastatic lymph nodes (82.9%) were smaller than 5 mm in diameter. Internal iliac, obturator regions and middle rectal root were more likely to be involved by tumors. Patients with lateral metastasis suffered more recurrence and poorer survival.
Lateral pelvic metastasis could be observed in low rectal cancer and its incidence differed among lateral pelvic regions. Patients with lateral spread predisposed poor prognosis, thus underlies the value of pre/postoperative adjuvant therapy.
研究低位直肠癌的侧方盆腔转移及微转移情况，并阐明其预后价值。
对67例低位直肠癌患者的侧方盆腔标本进行全层切片和组织芯片检查，并对纳入病例进行随访。
12例标本诊断为侧方转移，另有10例证实有微转移。大多数受累转移淋巴结（82.9%）直径小于5mm。髂内、闭孔区和直肠中根部更易被肿瘤累及。发生侧方转移的患者复发更多，生存更差。
低位直肠癌可出现侧方盆腔转移，且其发生率在侧方盆腔各区域有所不同。发生侧方扩散的患者预后较差，因此凸显了术前/术后辅助治疗的价值。
