真核生物起始因子4E

Eukaryotic initiation factor 4E.

作者信息

Goodfellow Ian G, Roberts Lisa O

机构信息

Department of Virology, Imperial College London, Norfolk Place, London W2 1PG, UK.

出版信息

Int J Biochem Cell Biol. 2008;40(12):2675-80. doi: 10.1016/j.biocel.2007.10.023. Epub 2007 Oct 24.

DOI:10.1016/j.biocel.2007.10.023

PMID:18069043

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3061223/

Abstract

Eukaryotic translation initiation factor 4E (eIF4E) is perhaps best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. However, recent studies have highlighted that eIF4E has many additional functions, which include the nuclear export of specific mRNAs as well as roles in ageing and the translation of some uncapped viral RNAs. This review aims to update the reader on recent developments, including the potential of eIF4E as a therapeutic target.

摘要

真核生物翻译起始因子4E（eIF4E）可能因其在细胞质中加帽mRNA上的蛋白质合成起始过程中的功能而最为人所知。然而，最近的研究强调，eIF4E还有许多其他功能，包括特定mRNA的核输出以及在衰老和一些未加帽病毒RNA翻译中的作用。这篇综述旨在向读者介绍最新进展，包括eIF4E作为治疗靶点的潜力。