Jarrold C R, Allaker R P, Young K A, Heath M R, Hardie J M, Lynch E
Department of Oral Microbiology, St Bartholomew's & The Royal London School of Medicine & Dentistry, London, UK.
Br Dent J. 1997 Jul 26;183(2):51-6.
To evaluate a 2% w/w minocycline gel (Dentomycin) in the treatment of older adults with chronic periodontitis.
Vehicle-controlled, split-mouth
Dental Institute, St Bartholomew's and the Royal London School of Medicine and Dentistry.
22 adults (mean age 60 years).
At baseline, patients received scaling and root planing. Test and placebo were applied at contralateral disease sites surrounding 22 test and 22 control teeth at baseline, and at weeks 2 and 4.
Probing pocket depth, bleeding on probing and supragingival plaque measurements, and microbiological sampling, at one pocket site per tooth were undertaken at baseline, and at weeks 2, 4, 6 and 16.
Microbial counts of Porphyromonas gingivalis, Prevotella intermedia and Eikenella corrodens did not change significantly over 16 weeks. No significant reductions in bleeding on probing and supragingival plaque score occurred with either gel. A larger reduction in mean pocket depth, from baseline to week 16, was found at test (6.50 to 4.95 mm; 24% reduction; P < 0.01) than at control sites (6.41 to 5.53 mm; 14% reduction; P < 0.05).
Minocycline gel administration is a useful adjunct to scaling and root planing in the treatment of older adults with periodontitis.
评估2%w/w米诺环素凝胶（Dentomycin）治疗老年慢性牙周炎患者的效果。
赋形剂对照、双侧对照
圣巴塞洛缪医院及伦敦皇家医学院牙科学院牙科研究所
22名成年人（平均年龄60岁）
基线时，患者接受龈下刮治和根面平整。在基线、第2周和第4周时，在22颗试验牙和22颗对照牙周围的对侧病变部位分别应用试验药物和安慰剂。
在基线、第2、4、6和16周时，对每颗牙齿的一个牙周袋部位进行探诊深度、探诊出血和龈上菌斑测量以及微生物采样。
牙龈卟啉单胞菌、中间普氏菌和腐蚀埃肯菌的微生物计数在16周内无显著变化。两种凝胶在探诊出血和龈上菌斑评分方面均未出现显著降低。从基线到第16周，试验部位的平均牙周袋深度降低幅度更大（从6.50毫米降至4.95毫米；降低24%；P<0.01），而对照部位的降低幅度为（从6.41毫米降至5.53毫米；降低14%；P<0.05）。
在治疗老年牙周炎患者时，应用米诺环素凝胶是龈下刮治和根面平整的有益辅助治疗方法。
