Shimizu Kazuyuki
Nagoya City Midori General Hospital.
Nihon Rinsho. 2007 Dec;65(12):2218-22.
The International Myeloma Working Group (IMWG) has recently proposed a new classification of asymptomatic myeloma and symptomatic myeloma. The distinction between asymptomatic and symptomatic myeloma depends on the presence or absence of the myeloma-related organ or tissue impairment (ROTI) defined by the IMWG. Based on the definition, some patients without clinical symptoms may fall into the "symptomatic" group because of insidious organ impairment by myeloma. Or others with clinical symptoms may fall into "asymptomatic" group, if no organ impairment is proven to be myeloma related. Recognition of the clinical features developed by ROTI is not only important for the diagnosis of symptomatic myeloma but also for the immediate institution of effective treatment. Immediate and proper management of the clinical features of symptomatic myeloma patients will have a great impact on quality of life and survival.
国际骨髓瘤工作组（IMWG）最近提出了无症状骨髓瘤和有症状骨髓瘤的新分类。无症状骨髓瘤和有症状骨髓瘤的区分取决于IMWG定义的骨髓瘤相关器官或组织损害（ROTI）的有无。根据该定义，一些没有临床症状的患者可能由于骨髓瘤隐匿性器官损害而属于“有症状”组。或者其他有临床症状的患者，如果没有证据证明器官损害与骨髓瘤相关，则可能属于“无症状”组。认识由ROTI产生的临床特征不仅对有症状骨髓瘤的诊断很重要，而且对立即开始有效治疗也很重要。对有症状骨髓瘤患者临床特征的及时、恰当处理将对生活质量和生存产生重大影响。
