Vanheste S, Vereecken P, Lambermont M, Heenen M, Bron D
Service de Dermatologie, Hôpital Erasme, Bruxelles.
Rev Med Brux. 2007 Sep-Oct;28(5):445-51.
Extracorporeal photochemotherapy is an immunomodulatory treatment wich is carried out in three steps: first leukapheresis, then ex vivo PUVA treatment and finally autologous transfusion. Its current "evidence-based" indications are erythrodermic cutaneous lymphoma, graft versus host disease and cardiac graft rejection. However this treatment has already been used with success in many other diseases such as systemic sclerosis, multiple sclerosis, type 1 diabetes and various autoimmune dermatologic diseases. Randomised controlled studies are needed to confirm the efficacy of photopheresis in these diseases. We also review the different hypotheses explaining the mechanism of action of photopheresis.
体外光化学疗法是一种免疫调节治疗方法，分三步进行：首先是白细胞单采，然后是体外补骨脂素加紫外线A治疗，最后是自体输血。其目前基于“证据”的适应症为红皮病型皮肤淋巴瘤、移植物抗宿主病和心脏移植排斥反应。然而，这种治疗方法已在许多其他疾病中成功应用，如系统性硬化症、多发性硬化症、1型糖尿病和各种自身免疫性皮肤病。需要进行随机对照研究来证实光分离置换法在这些疾病中的疗效。我们还综述了解释光分离置换法作用机制的不同假说。
