Haydl H, Waldhäusl W
Wien Klin Wochenschr. 1975 Jun 27;87(13):401-6.
The clinical significance of the direct determination of plasma ACTH was investigated in healthy persons and in patients with primary or secondary adrenocortical insufficiency, with Cushing's syndrome or with acromegaly. The sensitivity of the radioimmunological method facilitated the detection of diurnal changes in plasma ACTH in healthy subjects and of variations in plasma ACTH after the administration of dexamethasone and glucagon. The determination of plasma ACTH appears to be a useful procedure of diagnostic value in patients suffering from primary adrenal insufficiency accompanied by high concentrations of plasma ACTH. However, in patients suffering from Cushing's syndrome or secondary adrenocortical insufficiency it is still essential to carry out the dexamethasone suppression test or the metopiron test, respectively.
研究了直接测定血浆促肾上腺皮质激素（ACTH）在健康人以及原发性或继发性肾上腺皮质功能不全、库欣综合征或肢端肥大症患者中的临床意义。放射免疫法的敏感性有助于检测健康受试者血浆ACTH的昼夜变化以及地塞米松和胰高血糖素给药后血浆ACTH的变化。测定血浆ACTH似乎是诊断原发性肾上腺功能不全且血浆ACTH浓度升高患者的一种有用的诊断方法。然而，对于库欣综合征或继发性肾上腺皮质功能不全患者，分别进行地塞米松抑制试验或甲吡酮试验仍然至关重要。
