Sakai Tsutomu, Oshima Akihiko, Nozaki Yusuke, Ida Itsuro, Haga Chie, Akiyama Haruhiko, Nakazato Yoichi, Mikuni Masahiko
Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan.
Neuropathology. 2008 Apr;28(2):143-50. doi: 10.1111/j.1440-1789.2007.00867.x. Epub 2007 Dec 5.
There is evidence that GABAergic neurotransmission is altered in mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). The calcium-binding proteins (CBPs) calbindin (CB), calretinin (CR), and parvalbumin (PV) are used as markers of specific subpopulations of cortical GABAergic interneurons. We examined the postmortem prefrontal cortical region (Brodmann's area 9) of patients with SCZ and BPD, and of age-matched control subjects, excluding suicide cases. The laminar density of neurons immunoreactive (IR) for three CBPs, namely CB, CR, and PV, was quantified. The densities of CB-IR neurons in layer 2 and PV-IR neurons in layer 4 in the SCZ subjects decreased compared with those in the control subjects. When CBP-IR neurons were classified according to their size, a reduction in the density of medium CB-IR neurons in layer 2 in SCZ subjects and an increase in the density of large CR-IR neurons in layer 2 in BPD subjects were observed. These results suggest that alterations in specific GABAergic neurons are present in mental disorders, and that such alterations may reflect the vulnerability toward the disorders.
有证据表明，在精神分裂症（SCZ）和双相情感障碍（BPD）等精神疾病中，γ-氨基丁酸能神经传递会发生改变。钙结合蛋白（CBP）钙结合蛋白（CB）、钙视网膜蛋白（CR）和小白蛋白（PV）被用作皮质γ-氨基丁酸能中间神经元特定亚群的标志物。我们检查了SCZ和BPD患者以及年龄匹配的对照受试者（排除自杀病例）的死后前额叶皮质区域（布罗德曼9区）。对三种CBP（即CB、CR和PV）免疫反应阳性（IR）的神经元的层状密度进行了量化。与对照受试者相比，SCZ受试者第2层中CB-IR神经元的密度和第4层中PV-IR神经元的密度降低。当根据CBP-IR神经元的大小进行分类时，观察到SCZ受试者第2层中型CB-IR神经元的密度降低，而BPD受试者第2层中大CR-IR神经元的密度增加。这些结果表明，精神疾病中存在特定γ-氨基丁酸能神经元的改变，并且这种改变可能反映了对这些疾病的易感性。
