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老年人心力衰竭的管理

Management of heart failure in elderly people.

作者信息

Imazio M, Cotroneo A, Gaschino G, Chinaglia A, Gareri P, Lacava R, Voci T D, Trinchero R

机构信息

Cardiology Department, Maria Vittoria Hospital, Torino, Italy.

出版信息

Int J Clin Pract. 2008 Feb;62(2):270-80. doi: 10.1111/j.1742-1241.2007.01583.x. Epub 2007 Dec 7.

Abstract

AIMS

To review currently available knowledge on presentation, clinical features and management of heart failure (HF) in elderly people.

METHODS

To review currently available evidence, we performed a thorough search of several evidence-based sources of information, including Cochrane Database of Systematic Reviews, Clinical Evidence, Evidence-based guidelines from National Guidelines Clearinghouse and a comprehensive MEDLINE search with the MeSH terms: 'heart failure', 'elderly' and 'management'.

RESULTS

A number of features of ageing may predispose elderly people to HF, and may impair the ability to respond to injuries. Another hallmark of elderly patients is the increasing prevalence of multiple coexisting chronic conditions and geriatric syndromes that may complicate the clinical presentation and evolution of HF. Although diagnosis may be challenging, because atypical symptoms and presentations are common, and comorbid conditions may mimic or complicate the clinical picture, diagnostic criteria do not change in elderly people. Drug treatment is not significantly different from that recommended in younger patients, and largely remains empiric, because clinical trials have generally excluded elderly people and patients with comorbid conditions. Disease management programmes may have the potential to reduce morbidity and mortality for patients with HF.

CONCLUSIONS

Heart failure is the commonest reason for hospitalisation and readmission among older adults. HF shows peculiar features in elderly people, and is usually complicated by comorbidities, presenting a significant financial burden worldwide, nevertheless elderly people have been generally excluded from clinical trials, and thus management largely remains empiric and based on evidence from younger age groups.

摘要

目的

综述目前关于老年人心力衰竭(HF)的临床表现、临床特征及管理的现有知识。

方法

为综述现有证据,我们对多个循证信息来源进行了全面检索,包括Cochrane系统评价数据库、临床证据、国家指南交换中心的循证指南,以及使用医学主题词“心力衰竭”“老年人”和“管理”进行的全面MEDLINE检索。

结果

衰老的一些特征可能使老年人易患HF,并可能损害其对损伤的反应能力。老年患者的另一个特点是多种并存慢性病和老年综合征的患病率不断增加,这可能使HF的临床表现和病情发展复杂化。尽管诊断可能具有挑战性,因为非典型症状和表现很常见,且合并症可能会模仿或使临床表现复杂化,但老年人的诊断标准并未改变。药物治疗与年轻患者推荐的治疗方法没有显著差异,并且在很大程度上仍然是经验性的,因为临床试验通常排除了老年人和合并症患者。疾病管理计划可能有潜力降低HF患者的发病率和死亡率。

结论

心力衰竭是老年人住院和再次住院的最常见原因。HF在老年人中表现出特殊特征,并且通常伴有合并症,在全球范围内带来了重大经济负担,然而老年人通常被排除在临床试验之外,因此管理在很大程度上仍然是经验性的,基于来自年轻人群体的证据。

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