Gillitzer Rolf, Hampel Christian, Wiesner Christoph, Hadaschik Boris, Thüroff Joachim
Department of Urology, Johannes-Gutenberg University, Mainz, Germany.
BJU Int. 2008 Apr;101(8):964-8. doi: 10.1111/j.1464-410X.2007.07347.x. Epub 2007 Dec 7.
To assess primary tumours of the urethra in males.
We retrospectively reviewed our database from 1986 to 2006 for primary tumours of the male urethra; nine patients with primary tumours of the urethra were analysed and follow-up information was obtained.
Three patients had tumours of the prostatic urethra, two of which had proliferating focal inflammation and one a low-grade, superficial urothelial cancer. All patients were treated successfully with transurethral resection. Six patients had carcinoma of the bulbar or penile urethra, including two with previous local percutaneous radiotherapy for prostate cancer. All had primary surgical excision that was adapted to tumour location and extension. One patient had adjuvant chemotherapy after surgery. All but one patient remain recurrence-free after a median follow-up of 20 months.
Primary carcinoma of the male urethra is a rare entity. Previous radiotherapy might be a predisposing factor. Local surgical tumour control is essential for long-term survival, but the extent of surgery depends on tumour location and stage. Multimodal therapy might be required to obtain an optimum oncological outcome.
评估男性尿道原发性肿瘤。
我们回顾性分析了1986年至2006年数据库中男性尿道原发性肿瘤患者；对9例尿道原发性肿瘤患者进行分析并获取随访信息。
3例患者为前列腺尿道肿瘤，其中2例伴有局灶性增生性炎症，1例为低级别浅表性尿路上皮癌。所有患者均经尿道切除术成功治疗。6例患者为球部或阴茎部尿道癌，其中2例曾接受过前列腺癌局部经皮放疗。所有患者均接受了根据肿瘤位置和范围进行的原发性手术切除。1例患者术后接受了辅助化疗。中位随访20个月后，除1例患者外，其余患者均无复发。
男性尿道原发性癌是一种罕见疾病。既往放疗可能是一个诱发因素。局部手术控制肿瘤对长期生存至关重要，但手术范围取决于肿瘤位置和分期。可能需要多模式治疗以获得最佳肿瘤学结局。
