Reimers Kerstin, Choi Claudia Yu, Bucan Vesna, Vogt Peter M
Department for Plastic, Hand, Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, D-30659 Hannover, Germany.
Int J Biol Sci. 2007 Nov 22;3(7):471-6. doi: 10.7150/ijbs.3.471.
The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties.
保守蛋白结构域UPF0005是一种在包括真菌和细菌在内的许多物种中分布的蛋白质家族特征。尽管该基序的功能未知，但已在新鉴定的包含BI-1家族的抗凋亡蛋白中发现，即Bax抑制蛋白-1（BI-1）、救生员（LFG）和h-GAAP。在寻找可能属于BI-1家族的脊椎动物蛋白时，我们发现生长激素诱导跨膜蛋白（Ghitm）是BI-1家族的另一个潜在成员。在此，我们在首次分析中对Ghitm的系统发育、在癌细胞系中的表达以及蛋白质组学特性进行了表征。
