Toll样受体9介导的DNA识别

TLR9-mediated recognition of DNA.

作者信息

Müller Thomas, Hamm Svetlana, Bauer Stefan

机构信息

Institut fur Immunology, Philipps-Universitat marburg, Marburg, Germany.

出版信息

Handb Exp Pharmacol. 2008(183):51-70. doi: 10.1007/978-3-540-72167-3_3.

DOI:10.1007/978-3-540-72167-3_3

PMID:18071654

Abstract

The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive immune response. Toll-like receptor 9 (TLR9) recognizes deoxyribonucleic acid (DNA) leading to cellular activation and cytokine production influencing the immune response against viruses and bacteria. The stimulation of TLR9 will be exploited for adjuvant therapy and treatment of cancer or allergy. In this review we will discuss TLR9 ligands, TLR9 expression, signaling, and the therapeutic potential of TLR9 ligands in treatment of infectious or allergic diseases and cancer.

摘要

哺乳动物免疫系统通过模式识别受体（PRR）感知病原体并做出激活反应。由13种受体组成的Toll样受体（TLR）家族在此过程中发挥着关键作用。TLR介导的信号传导激活免疫细胞，并引发先天性免疫反应，随后启动适应性免疫反应。Toll样受体9（TLR9）识别脱氧核糖核酸（DNA），导致细胞激活和细胞因子产生，影响针对病毒和细菌的免疫反应。TLR9的刺激将被用于辅助治疗以及癌症或过敏症的治疗。在本综述中，我们将讨论TLR9配体、TLR9表达、信号传导以及TLR9配体在治疗感染性或过敏性疾病及癌症方面的治疗潜力。